Site preparation is underway at the former Zellers store in Sarnia.
Giant Tiger spokesperson Alison Scarlett says the building is being prepared for construction.
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The new retail outlet will occupy about 23,000 sq ft at the west end of the former Zellers building on London Rd.
Giant Tiger will be hiring between 30 and 40 full and part time employees for the new Sarnia location.
Residents can apply online at www.gianttiger.com